A simple, sensitive, precise and accurate new uv-visible spectrophotometric method has been developed for estimation of ibuprofen and carisoprodol in synthetic mixture. The method was based on employing simultaneous equation method for analysis of both drugs. The proposed method employs the derivatization of carisoprodol by reagent 1,2-Naphthoquinone-4-sulfonic acid sodium salt in the presence of borate buffer at optimize condition. Linearity range was observed in the concentration range of 40-90 μg/ml for carisoprodol and 80-180 μg/ml for Ibuprofen. The method involved simultaneous analysis based on the measurement of absorbance at two wavelengths, i.e, λmax of carisoprodol (251.60 nm) and λmax of ibuprofen (265.0 nm). The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The recovery was found to be 98.95-99.25 and 100.27-100.58 for carisoprodol and of ibuprofen respectively.
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